Talking about LLBLGen Pro: The leading O/R mapper - generator
Emmet recommended this tool and he uses it for some applications. I like that it seems to be extremely powerful. OTOH, there is a lot to it, and it presented a problem for spinup time for me when I came into the project that used it. Additionally, there will be a performance tradeoff, and I wonder where there might be some more surface exposure to the database than I am comfortable with for security.
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LLBLGen Pro: The leading O/R mapper - generator